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Article

Perturbations to the active site of phosphotriesterase.

Biochemistry - 25 Feb 1997

Kuo J M, Chae M Y, Raushel F M

Abstract excerpt

Phosphotriesterase catalyzes the hydrolysis of organophosphate nerve agents. Four amino acid residues, located within the active site pocket, were mutated in an effort to ascertain the roles that these groups play in the structure and function of this enzyme. Tryptophan-131 is located at the entrance to the binuclear metal center, and the indole ring is positioned to suggest that it could provide a hydrophobic...

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PMID: 9047295
DOI: 10.1021/bi962099l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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