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Article

Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters.

Protein engineering, design & selection : PEDS - 1 Jan 2011

Briseño-Roa Luis, Timperley Christopher M, Griffiths Andrew D, Fersht Alan R

Abstract excerpt

The most lethal organophosphorus nerve agents (NA), like sarin, soman, agent-VX and Russian-VX, share a methylphosphonate moiety. Pseudomonas diminuta phosphotriesterase (PTE) catalyses the hydrolysis of methylphosphonate NA analogues with a catalytic efficiency orders of magnitude lower than that towards the pesticide paraoxon. With a view to obtaining PTE variants that more readily accept methylphosphonate NA,...

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PMID: 21037279
DOI: 10.1093/protein/gzq076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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