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Article

Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.

Biochemistry - 14 Aug 2012

Tsai Ping-Chuan, Fox Nicholas, Bigley Andrew N, Harvey Steven P, Barondeau David P, Raushel Frank M

Abstract excerpt

Phosphotriesterase (PTE) from soil bacteria is known for its ability to catalyze the detoxification of organophosphate pesticides and chemical warfare agents. Most of the organophosphate chemical warfare agents are a mixture of two stereoisomers at the phosphorus center, and the S(P)-enantiomers are significantly more toxic than the R(P)-enantiomers. In previous investigations, PTE variants were created through...

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PMID: 22809162
DOI: 10.1021/bi300811t
PMCID: PMC3447986

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