Article
Enhancing Paraoxon Binding to Organophosphorus Hydrolase Active Site.
International journal of molecular sciences - 23 Nov 2021
El Khoury Léa, Mobley David L, Ye Dongmei, Rempe Susan B
Abstract excerpt
Organophosphorus hydrolase (OPH) is a metalloenzyme that can hydrolyze organophosphorus agents resulting in products that are generally of reduced toxicity. The best OPH substrate found to date is diethyl p-nitrophenyl phosphate (paraoxon). Most structural and kinetic studies assume that the binding orientation of paraoxon is identical to that of diethyl 4-methylbenzylphosphonate, which is the only substrate...
Topics
- Aryldialkylphosphatase
- Catalytic Domain
- Crystallography, X-Ray
- Models, Molecular
- Molecular Dynamics Simulation
- Molecular Structure
- Mutation
- Paraoxon
- Protein Conformation