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Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR.

Biochemistry - 8 Sept 2015

Bigley Andrew N, Mabanglo Mark F, Harvey Steven P, Raushel Frank M

Abstract excerpt

The V-type organophosphorus nerve agents are among the most hazardous compounds known. Previous efforts to evolve the bacterial enzyme phosphotriesterase (PTE) for the hydrolytic decontamination of VX resulted in the identification of the variant L7ep-3a, which has a kcat value more than 2 orders of magnitude higher than that of wild-type PTE for the hydrolysis of VX. Because of the relatively small size of the...

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PMID: 26274608
DOI: 10.1021/acs.biochem.5b00629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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