Article
Expression of the LIS-1 gene product in brain anomalies with a migration disorder.
Pediatric neurology - 1 Jan 1997
Isumi H, Takashima S, Kakita A, Yamada M, Ikeda K, Mizuguchi M
Abstract excerpt
Miller-Dieker syndrome (MDS) is a prototype of brain malformations characterized by abnormal neuronal migration. To clarify the pathomechanisms underlying these anomalies, we performed immunohistochemical studies using specific antibodies against the protein product of LIS-1, the candidate gene responsible for the MDS phenotype. The LIS-1 protein was present abundantly and ubiquitously in normally developing...
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