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Article

Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects.

PLoS genetics - 1 Mar 2011

Pramparo Tiziano, Libiger Ondrej, Jain Sonia, Li Hong, Youn Yong Ha, Hirotsune Shinji, Schork Nicholas J, Wynshaw-Boris Anthony

Abstract excerpt

Heterozygous LIS1 mutations are the most common cause of human lissencephaly, a human neuronal migration defect, and DCX mutations are the most common cause of X-linked lissencephaly. LIS1 is part of a protein complex including NDEL1 and 14-3-3ε that regulates dynein motor function and microtubule dynamics, while DCX stabilizes microtubules and cooperates with LIS1 during neuronal migration and neurogenesis....

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Source

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Identifiers

PMID: 21423666
DOI: 10.1371/journal.pgen.1001331
PMCID: PMC3053345

Genes

DCX
NDEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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