Article
NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins.
Mechanisms of development - 1 Mar 2001
Sweeney K J, Prokscha A, Eichele G
Abstract excerpt
The LIS1-encoded protein (Lis1) plays a role in brain development because a hemizygous deletion or mutation of the human gene causes neuronal migration disorders, such as Miller-Dieker syndrome (MDS) or isolated lissencephaly sequence (ILS). Using a yeast two-hybrid screen, we have isolated a novel protein that interacts with mouse Lis1 (mLis1) which is termed mouse NudE-like protein (mNudE-L) because of its 49%...
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