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Article

Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration

1 May 1995

Abstract excerpt

Miller-Dieker lissencephaly syndrome (MDS) is a human developmental brain malformation caused by neuronal migration defects resulting in abnormal layering of the cerebral cortex. LIS1, the gene defective in MDS, encodes a subunit of brain platelet-activating factor (PAF) acetylhydrolase which inactivates PAF, a neuroregulatory molecule. We have isolated murine cDNAs homologous to human LIS1 and mapped these to...

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PMID: 7751941
DOI: 10.1523/jneurosci.15-05-03730.1995

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Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migrationPMID 7751941Read ↗

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