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Article

Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).

International journal of molecular medicine - 1 May 1998

Reiner O, Sapir T

Abstract excerpt

Lissencephaly is a relatively common brain malformation. Lissencephaly type 1 is characterized by the smooth appearance of the cortex and the presence of four abnormally positioned layers instead of the normal six. Lissencephaly is considered to be an abnormality in neuronal migration. The gene mutated in type 1 lissencephaly was cloned by us and designated LIS1. Recently, several genes involved in cortical...

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PMID: 9852306
DOI: 10.3892/ijmm.1.5.849

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Abnormal cortical development; towards elucidation of the LIS1 gene product function (review).PMID 9852306Read ↗

Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migrationSemantic proximity Read ↗

The location and type of mutation predict malformation severity in isolated lissencephaly caused by abnormalities within the LIS1 gene.Semantic proximity Read ↗

Developmental alterations of the septohippocampal cholinergic projection in a lissencephalic mouse model.Semantic proximity Read ↗

Genetic mechanisms underlying abnormal neuronal migration in classical lissencephaly.Semantic proximity Read ↗

[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?].Semantic proximity Read ↗

The role of cytoplasmic dynein in the human brain developmental disease lissencephaly.Semantic proximity Read ↗

Clinical and molecular basis of classical lissencephaly: Mutations in the LIS1 gene (PAFAH1B1).Semantic proximity Read ↗

Lissencephaly: Expanded imaging and clinical classification.Semantic proximity Read ↗

Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development.Semantic proximity Read ↗

LIS1-no more no less.Semantic proximity Read ↗

The genetics of lissencephaly.Semantic proximity Read ↗

Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly.Semantic proximity Read ↗

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