Article
Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
British journal of cancer - 1 Jan 1997
Lou M A, Tseng S L, Chang S F, Yue C T, Chang B L, Chou C H, Yang S L, Teh B H, Wu C W, Shen C Y
Abstract excerpt
Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
