High frequency of p53 gene mutations in primary breast cancers in Japanese women, a low-incidence population.

doi:10.1038/bjc.1996.179

Article

High frequency of p53 gene mutations in primary breast cancers in Japanese women, a low-incidence population.

British journal of cancer - 1 Apr 1996

Hartmann A, Blaszyk H, Saitoh S, Tsushima K, Tamura Y, Cunningham J M, McGovern R M, Schroeder J J, Sommer S S, Kovach J S

Abstract excerpt

The pattern of acquired mutations in the p53 tumour-suppressor gene is potentially useful for determining factors contributing to carcinogenesis in diverse populations differing in incidence and/or mortality from the disease. We previously reported differences in mutational patterns of the p53 ge...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Breast Neoplasms
Female
Genes, p53
Humans
Immunohistochemistry
Middle Aged
Mutation
Tumor Suppressor Protein p53

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