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Article

Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification.

Oncogene - 1 Jun 1991

Kahn S M, Jiang W, Culbertson T A, Weinstein I B, Williams G M, Tomita N, Ronai Z

Abstract excerpt

We have developed a rapid and highly sensitive nonradioactive method for the detection of a mutant codon 12 human c-K-ras allele in the presence of as many as 10(4) copies of the wild type codon 12 allele. This sensitivity is achieved by selective polymerase chain reaction (PCR) amplification of mutant K-ras gene sequences employing a two stage procedure. The first stage entails the amplification of both K-ras...

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PMID: 1676837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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