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Article

Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population.

Brain research. Molecular brain research - 1 Mar 1995

Oyama F, Shimada H, Oyama R, Ihara Y

Abstract excerpt

We have investigated the effect of genotypes of apolipoprotein E (ApoE) on the pathologies found in Alzheimer's disease (AD) and its related gene expression in 38 aged human brains obtained from consecutive autopsied cases. ApoE2/3, -3/3, -3/4, and -4/4 were typed in those aged brains, with ApoE3/3 being most prevalent. The AD pathologies were undetectable in ApoE2/3 brains, but were frequently observed in the...

Topics

Aged
Aged, 80 and over
Aging
Alzheimer Disease
Amyloid beta-Protein Precursor
Apolipoproteins E
Base Sequence
Gene Expression
Genotype
Humans
Middle Aged
Molecular Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

RNA, Messenger

tau Proteins

Source

Identifiers

PMID: 7770005
DOI: 10.1016/0169-328x(94)00233-5

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7770005-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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