Article
APOE and cerebral amyloid angiopathy in community-dwelling older persons.
Neurobiology of aging - 1 Nov 2015
Yu Lei, Boyle Patricia A, Nag Sukriti, Leurgans Sue, Buchman Aron S, Wilson Robert S, Arvanitakis Zoe, Farfel Jose M, De Jager Philip L, Bennett David A, Schneider Julie A
Abstract excerpt
Both cerebral amyloid angiopathy and Alzheimer's disease pathology involve abnormal β-amyloid processing. We aim to elucidate the relationship of the apolipoprotein E (APOE) genotypes with amyloid angiopathy in the presence of variable amounts of Alzheimer's pathology. Data came from 1062 autopsied subjects from 2 community-based studies of aging. Common neuropathologies including Alzheimer's disease and amyloid...
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