APOE and cerebral amyloid angiopathy in the elderly.

doi:10.1097/00001756-200308060-00027

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Article

APOE and cerebral amyloid angiopathy in the elderly.

Neuroreport - 6 Aug 2003

Love Seth, Nicoll James A R, Hughes Anthony, Wilcock Gordon K

Abstract excerpt

Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD or cerebral haemorrhage. Prevalence of CAA increased with age (p = 0.003). CAA was not...

Topics

Aged
Aging
Apolipoproteins E
Brain
Brain Chemistry
Cerebral Amyloid Angiopathy
Female
Genotype
Humans
Immunohistochemistry
Logistic Models
Longevity
Male
Middle Aged
Paraffin Embedding
Sex Characteristics

Source

Open in PubMed

Identifiers

PMID: 12960780
DOI: 10.1097/00001756-200308060-00027

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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