Article
Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas.
The Journal of clinical endocrinology and metabolism - 1 Oct 1996
Tahara H, Smith A P, Gaz R D, Arnold A
Abstract excerpt
Rearrangement and overexpression of the PRAD1/cyclin D1 oncogene, a cell cycle regulator, have been implicated in the pathogenesis of a subset of parathyroid adenomas. Recently, two cell cycle regulators that inhibit the cyclin D1-associated kinases cdk4 and cdk6 have been identified: p16 and p15...
Topics
- Base Sequence
- Blotting, Southern
- Carrier Proteins
- Cell Cycle Proteins
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- DNA
- Enzyme Inhibitors
- Gene Deletion
- Humans
- Molecular Sequence Data
- Mutation
- Parathyroid Neoplasms
- Polymorphism, Single-Stranded Conformational
- Protein Kinase Inhibitors
- Tumor Suppressor Proteins