Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas.

The Journal of clinical endocrinology and metabolism - 1 Oct 1996

Tahara H, Smith A P, Gaz R D, Arnold A

Abstract excerpt

Rearrangement and overexpression of the PRAD1/cyclin D1 oncogene, a cell cycle regulator, have been implicated in the pathogenesis of a subset of parathyroid adenomas. Recently, two cell cycle regulators that inhibit the cyclin D1-associated kinases cdk4 and cdk6 have been identified: p16 and p15, the products of the INK4A (also known as CDKN2, MTS1) and INK4B (also known as MTS2) putative tumor suppressor genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Gene Deletion

Share to Molecular Sequence Data

Share to Mutation

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 8855819
DOI: 10.1210/jcem.81.10.8855819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas.PMID 8855819Read ↗

Genomic localization of novel candidate tumor suppressor gene loci in human parathyroid adenomas.Semantic proximity Read ↗

Novel Chromosomal Abnormalities Identified by Comparative Genomic Hybridization in Parathyroid Adenomas1Semantic proximity Read ↗

Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma.Semantic proximity Read ↗

Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.Semantic proximity Read ↗

Loss of p16 (INK4A) expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected malignant peripheral nerve sheath tumors.Semantic proximity Read ↗

Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.Semantic proximity Read ↗

Molecular analysis of cyclin-dependent kinase inhibitors in human leukemias.Semantic proximity Read ↗

Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.Semantic proximity Read ↗

p53 abnormalities in human parathyroid carcinoma.Semantic proximity Read ↗

Parathyroid tumor suppressor on 1p: analysis of the p18 cyclin-dependent kinase inhibitor gene as a candidate.Semantic proximity Read ↗

Deletion of the p16 and p15 Genes in Human Bladder TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.