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Article

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 1997

Wilson C L, Heppner K J, Labosky P A, Hogan B L, Matrisian L M

Abstract excerpt

Matrix metalloproteinases (MMPs) classically have been implicated in basement membrane destruction associated with late-stage tumor cell invasion and metastasis. However, recent studies have demonstrated that one MMP family member, matrilysin, is expressed in a high percentage of early-stage human colorectal tumors. We analyzed matrilysin expression in benign intestinal tumors from mice heterozygous for the...

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Identifiers

PMID: 9037065
DOI: 10.1073/pnas.94.4.1402
PMCID: PMC19803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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