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Article

High specificity of human secretory class II phospholipase A2 for phosphatidic acid.

The Biochemical journal - 1 Feb 1997

Snitko Y, Yoon E T, Cho W

Abstract excerpt

Lysophosphatidic acid (LPA) is a potent lipid second messenger which stimulates platelet aggregation, cell proliferation and smooth-muscle contraction. The phospholipase A2 (PLA2)-catalysed hydrolysis of phosphatidic acid (PA) is thought to be a primary synthetic route for LPA. Of the multiple forms of PLA2 present in human tissues, human secretory class-II PLA2 (hs-PLA2) has been implicated in the production of...

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Identifiers

PMID: 9032461
DOI: 10.1042/bj3210737
PMCID: PMC1218130

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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