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Article

Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients.

Journal of human genetics - 1 Jan 2004

Ishihara Mitsuaki, Iwasaki Tadao, Nagano Makoto, Ishii Jun, Takano Mayumi, Kujiraoka Takeshi, Tsuji Masahiro, Hattori Hiroaki, Emi Mitsuru

Abstract excerpt

Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor (PAF) acetylhydrolase (PAF-AH), is a member of the serine-dependent class of A2 phospholipases that hydrolyze sn2-ester bonds of fragmented or oxidized phospholipids at sites where atherosclerotic plaques are forming. Most circulating Lp-PLA2 is bound to low-density lipoprotein (LDL) particles in plasma and the rest...

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Identifiers

PMID: 15148590
DOI: 10.1007/s10038-004-0151-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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