Article
Saposin A mobilizes lipids from low cholesterol and high bis(monoacylglycerol)phosphate-containing membranes: patient variant Saposin A lacks lipid extraction capacity.
The Journal of biological chemistry - 27 Oct 2006
Locatelli-Hoops Silvia, Remmel Natascha, Klingenstein Ralf, Breiden Bernadette, Rossocha Maksim, Schoeniger Maike, Koenigs Christine, Saenger Wolfram, Sandhoff Konrad
Abstract excerpt
Saposin A (Sap-A) is one of five known sphingolipid activator proteins required for the lysosomal degradation of sphingolipids and for the loading of lipid antigens onto antigen-presenting molecules of the CD1 type. Sap-A assists in the degradation of galactosylceramide by galactosylceramide-beta-galactosidase in vivo, which takes place at the surface of intraendosomal/intralysosomal vesicles. Sap-A is believed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.