Article
Unique membrane interaction mode of group IIF phospholipase A2.
The Journal of biological chemistry - 27 Oct 2006
Wijewickrama Gihani T, Albanese Alexandra, Kim Young Jun, Oh Youn Sang, Murray Paul S, Takayanagi Risa, Tobe Takashi, Masuda Seiko, Murakami Makoto, Kudo Ichiro, Ucker David S, Murray Diana, Cho Wonhwa
Abstract excerpt
The mechanisms by which secretory phospholipases A(2) (PLA(2)s) exert cellular effects are not fully understood. Group IIF PLA(2) (gIIFPLA(2)) is a structurally unique secretory PLA(2) with a long C-terminal extension. Homology modeling suggests that the membrane-binding surface of this acidic PLA(2) contains hydrophobic residues clustered near the C-terminal extension. Vesicle leakage and monolayer penetration...
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