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Article

Relationship of p21-activated kinase (PAK) and filopodia to persistence and oncogenic transformation.

Journal of cellular physiology - 1 Sept 2009

Heckman Carol A, Demuth John G, Deters Donald, Malwade Santosh R, Cayer Marilyn L, Monfries Clinton, Mamais Adamantios

Abstract excerpt

Previously, we found that oncogenically transformed cells had fewer filopodia and more large, p21-activated kinase (PAK)-dependent features than normal cells. These large protrusions (LPs) were increased in cells expressing RhoA(N19) with Cdc42-associated kinase (ACK). Here, we determine how GTPase-mediated mechanisms of focal contact (FC) regulation affect these protrusions. Constructs encoding various proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19384897
DOI: 10.1002/jcp.21788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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