Article
Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008
Carl Joseph W, Liu Jin-Qing, Joshi Pramod S, El-Omrani Hani Y, Yin Lijie, Zheng Xincheng, Whitacre Caroline C, Liu Yang, Bai Xue-Feng
Abstract excerpt
Despite negative selection in the thymus, significant numbers of autoreactive T cells still escape to the periphery and cause autoimmune diseases when immune regulation goes awry. It is largely unknown how these T cells escape clonal deletion. In this study, we report that CD24 deficiency caused deletion of autoreactive T cells that normally escape negative selection. Restoration of CD24 expression on T cells...
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