Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene.

Abstract excerpt

Absence of CD4 impairs the efficiency of T cell receptor (TCR) signaling in response to major histocompatibility complex (MHC) class II-presented peptides. Here we use mice carrying a conditional Cd4 allele to study the consequences of impaired TCR signaling after the completion of thymocyte development. We show that loss of CD4 decreases the steady-state proliferation of T cells as monitored by in vivo labeling...

Topics

• Animals
• CD4 Antigens
• CD4-Positive T-Lymphocytes
• Cell Differentiation
• Female
• Humans
• Major Histocompatibility Complex
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic