Article
Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease.
The Journal of clinical investigation - 1 Feb 2006
Ma Cindy S, Pittaluga Stefania, Avery Danielle T, Hare Nathan J, Maric Irina, Klion Amy D, Nichols Kim E, Tangye Stuart G
Abstract excerpt
Individuals with X-linked lymphoproliferative disease (XLP) display defects in B cell differentiation in vivo. Specifically, XLP patients do not generate a normal number of CD27 memory B cells, and those few that are present are IgM. Recent studies have suggested that IgMCD27 B cells are not true memory cells, but rather B cells that guard against T cell-independent pathogens. Here we show that human XLP IgMCD27...
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