Article
Genetic susceptibility to cancer.
Cancer - 1 Aug 1993
Spitz M R, Bondy M L
Abstract excerpt
For any given level of exposure to a carcinogen, only a proportion of exposed individuals will develop cancer. Interindividual differences in susceptibility at some stage of the carcinogenic process must be postulated. One contributing factor is variation in the activity of metabolizing enzymes responsible for conversion of procarcinogens to proximate carcinogens. There is also a wide spectrum of DNA repair...
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