Article
Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 1997
Spitz M R, McPherson R S, Jiang H, Hsu T C, Trizna Z, Lee J J, Lippman S M, Khuri F R, Steffen-Batey L, Chamberlain R M, Schantz S P, Hong W K
Abstract excerpt
Although tobacco and alcohol use are the major determinants of upper aerodigestive tract carcinogenesis, not all smokers develop cancer. This phenomenon is due to individual variation in genetic susceptibility to carcinogens. One explanation may be differences in mutagen sensitivity (as measured by the in vitro bleomycin-induced mutagen sensitivity assay) in patients with squamous cell carcinoma of the upper...
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