gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay.

doi:10.1158/1055-9965.EPI-05-0353

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Article

gamma-Radiation-induced chromosomal mutagen sensitivity is associated with breast cancer risk in African-American women: caffeine modulates the outcome of mutagen sensitivity assay.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2006

Natarajan Thanemozhi G, Ganesan Natarajan, Carter-Nolan Pamela, Tucker Cynthia A, Shields Peter G, Adams-Campbell Lucile L

Abstract excerpt

Several different cancer studies have indicated that lymphocyte mutagen sensitivity is a marker of DNA repair deficiency and increased cancer risk. We have used a mutagen sensitivity assay (MSA) measuring gamma-radiation-induced chromosomal aberrations in freshly cultured lymphocytes and assessed breast cancer risk in African-American women. Concurrently, we conducted duplicate cultures in the presence of...

Topics

Adult
Black or African American
Age Distribution
Aged
Aged, 80 and over
Biomarkers, Tumor
Breast Neoplasms
Caffeine
Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cells, Cultured

Chromosome Aberrations

DNA Damage

Female

Gamma Rays

Genetic Predisposition to Disease

Humans

Incidence

Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 16537698
DOI: 10.1158/1055-9965.EPI-05-0353

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