Article
A role for p53 in the frequency and mechanism of mutation.
Mutation research - 1 Mar 2002
Morris Suzanne M
Abstract excerpt
The tumor suppressor protein, p53, is often referred to as the guardian of the genome. When p53 function is impaired, its ability to preserve genomic integrity is compromised. This may result in an increase in mutation on both a molecular and chromosomal level and contribute to the progression to a malignant phenotype. In order to study the effect of p53 function on the acquisition of mutation, in vitro and in...
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