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Article

Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia.

International journal of radiation biology - 1 Dec 1994

Meyn M S, Strasfeld L, Allen C

Abstract excerpt

We have obtained initial evidence supporting a new model for the human disease ataxia-telangiectasia (A-T), in which the A-T and p53 genes play crucial roles in a signal transduction network that activates multiple cellular functions in response to DNA damage. Three of the model's predictions were tested. (1) Disrupting cell cycle checkpoints should increase spontaneous rates in normal cells. In order to...

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PMID: 7836842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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