Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia.

Article

Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia.

International journal of radiation biology - 1 Dec 1994

Meyn M S, Strasfeld L, Allen C

Abstract excerpt

We have obtained initial evidence supporting a new model for the human disease ataxia-telangiectasia (A-T), in which the A-T and p53 genes play crucial roles in a signal transduction network that activates multiple cellular functions in response to DNA damage. Three of the model's predictions wer...

Topics

Apoptosis
Ataxia Telangiectasia
DNA
DNA-Binding Proteins
Fibroblasts
Genes, p53
Humans
Mutation
Oncogene Proteins, Viral
Phenotype
Recombination, Genetic
Streptonigrin
Transfection
Tumor Suppressor Protein p53

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