Follicular lymphoma immunoglobulin kappa light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains.

doi:10.1046/j.1365-2141.1997.8492477.x

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Article

Follicular lymphoma immunoglobulin kappa light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains.

British journal of haematology - 1 Jan 1997

Stamatopoulos K, Kosmas C, Papadaki T, Pouliou E, Belessi C, Afendaki S, Anagnostou D, Loukopoulos D

Abstract excerpt

Follicular lymphoma cells carry surface immunoglobulin whose heavy chain variable (VH) regions exhibit considerable divergence from the aminoacid sequence predicted by the germline nucleotide sequence as a result of the somatic hypermutation process. The present study examined the extent of somat...

Topics

Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Electrophoresis, Agar Gel
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Follicular

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 9012699
DOI: 10.1046/j.1365-2141.1997.8492477.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9012699-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.