Article
Clonality of dysplastic epithelium in colorectal adenomas from familial adenomatous polyposis patients.
Cancer research - 1 Feb 1997
Bjerknes M, Cheng H, Kim H, Schnitzler M, Gallinger S
Abstract excerpt
Loss of function of both alleles of the APC gene results in colorectal adenoma formation in familial adenomatous polyposis, an autosomal dominant genetic disorder leading to multiple colorectal tumors at an early age. Previous molecular studies indicate that the mutant cells forming dysplastic epithelium within adenomas are clonally derived. We show, using immunostaining and molecular techniques, that the...
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