Article
Top-down morphogenesis of colorectal tumors.
Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2001
Shih I M, Wang T L, Traverso G, Romans K, Hamilton S R, Ben-Sasson S, Kinzler K W, Vogelstein B
Abstract excerpt
One of the fundamental tenets of oncology is that tumors arise from stem cells. In the colon, stem cells are thought to reside at the base of crypts. In the early stages of tumorigenesis, however, dysplastic cells are routinely found at the luminal surface of the crypts whereas the cells at the bases of these same crypts appear morphologically normal. To understand this discrepancy, we evaluated the molecular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.