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Article

Enhanced stem cell survival in familial adenomatous polyposis.

The American journal of pathology - 1 Apr 2004

Kim Kyoung-Mee, Calabrese Peter, Tavaré Simon, Shibata Darryl

Abstract excerpt

Individuals with heterozygous germline adenomatous polyposis coli (APC) mutations or familial adenomatous polyposis (FAP) are born with normal appearing colons but later develop hundreds to thousands of polyps. Tumor progression apparently starts after somatic loss of the normal APC allele, but germline APC mutations may potentially alter niche stem cell survival through dominant-negative interactions or...

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Share to Adenomatous Polyposis Coli
Share to Cell Lineage
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to DNA Methylation

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Source

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Identifiers

PMID: 15039224
DOI: 10.1016/S0002-9440(10)63223-3
PMCID: PMC1615334

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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