Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

From gene mutations to tumours--stem cells in gastrointestinal carcinogenesis.

Cell proliferation - 1 Dec 2005

Leedham S J, Schier S, Thliveris A T, Halberg R B, Newton M A, Wright N A

Abstract excerpt

Stem cells share many properties with malignant cells, such as the ability to self-renew and proliferate. Cancer is believed to be a disease of stem cells. The gastrointestinal tract has high cancer prevalence partly because of rapid epithelial cell turnover and exposure to dietary toxins. The molecular pathways of carcinogenesis differ according to the tissue. Work on hereditary cancer syndromes including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APC gene
Share to FAP gene
Share to Genes, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

Share to Gastrointestinal Tract

Share to Mutation

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 16300652
DOI: 10.1111/j.1365-2184.2005.00359.x
PMCID: PMC6496903

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From gene mutations to tumours--stem cells in gastrointestinal carcinogenesis.PMID 16300652Read ↗

Gastrointestinal stem cells and cancer: bridging the molecular gap.Semantic proximity Read ↗

Stem cells and cancer of the stomach and intestineSemantic proximity Read ↗

Stem cells: the intestinal stem cell as a paradigmSemantic proximity Read ↗

Stem vs non-stem cell origin of colorectal cancer.Semantic proximity Read ↗

Investigating the fixation and spread of mutations in the gastrointestinal epithelium.Semantic proximity Read ↗

Colorectal cancer initiation: Understanding early-stage disease for intervention.Semantic proximity Read ↗

Stem cell relationships and the origin of gastrointestinal cancer.Semantic proximity Read ↗

Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.Semantic proximity Read ↗

[Stem cell theory of colorectal cancer and its connection with molecular-biological data].Semantic proximity Read ↗

Therapeutic implications of colon cancer stem cellsSemantic proximity Read ↗

Increased stem cell somatic mutation in the non-neoplastic colorectal mucosa of patients with familial adenomatous polyposis.Semantic proximity Read ↗

Stem cells and colorectal carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.