Article
Oncogenic activation of the alphaPDGFR defines a domain that negatively regulates receptor dimerization.
Oncogene - 16 Jan 1997
Uren A, Yu J C, Karcaaltincaba M, Pierce J H, Heidaran M A
Abstract excerpt
The alpha platelet derived growth factor receptor (alphaPDGFR) extracellular Immunoglobulin (Ig) like domains 1-3 contain major determinants for ligand interaction. We now report that a deletion of Ig-like loop 3, but not Ig-like loop 1 or 2, of the alphaPDGFR causes ligand-independent transforma...
Topics
- 3T3 Cells
- Animals
- Cell Transformation, Neoplastic
- Dimerization
- Enzyme Activation
- Epitopes
- Genetic Vectors
- Immunoglobulins
- Mice
- Mutation
- Phenotype
- Phosphorylation
- Receptor Protein-Tyrosine Kinases
- Receptors, Platelet-Derived Growth Factor
- Transfection