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Article

Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner.

Oncogene - 3 Dec 2009

di Martino E, L'Hôte C G, Kennedy W, Tomlinson D C, Knowles M A

Abstract excerpt

Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific effects in urothelial cells or the basis for the observed mutation spectrum. We investigated the phenotypic and signaling consequences of three FGFR3 mutations (S249C, Y375C, and K652E) in immortalized normal human urothelial cells (TERT-NHUC) and mouse...

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Topics

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Share to Amino Acid Substitution
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Phosphorylation

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to RNA, Small Interfering

Share to Urinary Bladder Neoplasms

Share to Urothelium

Source

Open in PubMed Open full text

Identifiers

PMID: 19749790
DOI: 10.1038/onc.2009.280
PMCID: PMC2789045

Genes

FGFR3
TERT
SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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