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Article

Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy.

Neoplasia (New York, N.Y.) - 1 Dec 2005

Cheng Hua, Langley Robert R, Wu Qiuyu, Wu Wenjuan, Feng Jie, Tsan Rachel, Fan Dominic, Fidler Isaiah J

Abstract excerpt

Tumor cells and tumor-associated endothelial cells express activated epidermal growth factor receptor (EGFR) due to production of EGF-related ligands in the tumor microenvironment. To investigate the effect of perpetual EGFR activation on endothelial cells, we developed a novel method to generate constitutively active EGFR. We fused the entire intracellular domain of the EGFR to the N-terminus of the CD3zeta...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16354589
DOI: 10.1593/neo.05553
PMCID: PMC1501175

Genes

EGFR
EGF

Provenance

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