Article
No abnormality in the gene for the G protein stimulatory alpha subunit in patients with bipolar disorder.
Archives of general psychiatry - 1 Jan 1997
Ram A, Guedj F, Cravchik A, Weinstein L, Cao Q, Badner J A, Goldin L R, Grisaru N, Manji H K, Belmaker R H, Gershon E S, Gejman P V
Abstract excerpt
BACKGROUND: The available evidence for an involvement of the heterotrimeric guanine-nucleotide-binding proteins (G proteins) in bipolar disorder relies primarily on the effects of lithium salts on G protein function and on alterations in the concentration or function of G proteins (most notably Gs-alpha) in peripheral leukocytes and in postmortem tissues of patients with bipolar disorder. METHODS: The hypothesis...
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