Article
Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression.
American journal of medical genetics - 8 Jul 2002
Zill Peter, Baghai Thomas C, Zwanzger Peter, Schüle Cornelius, Minov Christo, Behrens Stefanie, Rupprecht Rainer, Möller Hans-Jürgen, Engel Rolf, Bondy Brigitta
Abstract excerpt
Growing evidence suggests that G-proteins may be involved in pathogenesis and treatment of affective disorders. Several studies have reported altered levels and/or activities of stimulatory G-proteins in depression. The aim of this study was to investigate whether a polymorphism in the stimulatory alpha subunit of G-proteins (T/C point mutation in exon 5; ATT --> ATC at codon 131) is associated with major...
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