Article
Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jan 2006
Szczepankiewicz Aleksandra, Rybakowski Janusz K, Suwalska Aleksandra, Skibinska Maria, Leszczynska-Rodziewicz Anna, Dmitrzak-Weglarz Monika, Czerski Piotr M, Hauser Joanna
Abstract excerpt
A relationship between response to lithium prophylaxis and T-50C polymorphism of glycogen synthase kinase-3beta (GSK-3beta) gene was investigated in 89 bipolar patients (41 male and 48 female) who have been taking lithium for at least 5 years. The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be...
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