Article
Is lithium response related to G(s)alpha levels in transformed lymphoblasts from subjects with bipolar disorder?
Journal of affective disorders - 1 Jul 2001
Alda M, Keller D, Grof E, Turecki G, Cavazzoni P, Duffy A, Rouleau G A, Grof P, Young L T
Abstract excerpt
BACKGROUND: A series of studies from independent laboratories have found increased levels of G(s)alpha in bipolar disorder in postmortem brain and peripheral blood cells. Long-term lithium administration blunts G-protein coupled cAMP signaling and may regulate G(s)alpha levels. METHODS: We measured G(s)alpha in transformed lymphoblasts obtained from subjects with bipolar disorder and compared the findings with 23...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.