Article
Exclusion of close linkage of bipolar disorder to the Gs-alpha subunit gene in nine Australian pedigrees.
Journal of affective disorders - 1 Nov 1994
Le F, Mitchell P, Vivero C, Waters B, Donald J, Selbie L A, Shine J, Schofield P
Abstract excerpt
Growing evidence suggests that guanine nucleotide binding proteins (G proteins) may be involved in both the pathogenesis and treatment of bipolar affective disorder. Both overactive G proteins and increased levels of the alpha subunit of the stimulatory form (Gs-alpha) have been demonstrated in p...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Australia
- Bipolar Disorder
- Chromosomes, Human, Pair 20
- DNA Primers
- DNA, Recombinant
- Female
- Genetic Linkage
- Genotype
- Glycoprotein Hormones, alpha Subunit
- Humans
- Male
- Middle Aged
- Pedigree
- Polymerase Chain Reaction