Article
Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar.
The Journal of investigative dermatology - 1 Jan 2000
Lee S H, Shin M S, Kim H S, Park W S, Kim S Y, Jang J J, Rhim K J, Jang J, Lee H K, Park J Y, Oh R R, Han S Y, Lee J H, Lee J Y, Yoo N J
Abstract excerpt
Fas (Apo-1/CD95) is a cell-surface receptor involved in cell death signaling, and recent reports have suggested that defects within the Fas receptor pathway such as Fas mutation play an important part in the development and progression of human tumors. Burn scar-related squamous cell carcinoma of skin is a unique subtype of cutaneous squamous cell carcinoma, and tends to be more aggressive in nature than...
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