Article
p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2003
Bolshakov Svetlana, Walker Christopher M, Strom Sara S, Selvan Mano S, Clayman Gary L, El-Naggar Adel, Lippman Scott M, Kripke Margaret L, Ananthaswamy Honnavara N
Abstract excerpt
PURPOSE: The purpose is to investigate whether aggressive basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) differ from nonaggressive BCC and SCC with respect to the p53 mutation spectrum and whether specific mutations can serve as prognostic indicators of tumor aggressiveness. EXPERIMENTAL DESIGN: We analyzed 342 tissues from patients with aggressive and nonaggressive BCCs and SCCs for p53 mutations...
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