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Article

Cysteine mapping in the ion selectivity and toxin binding region of the cardiac Na+ channel pore.

The Journal of membrane biology - 1 Jan 1997

Chen S, Hartmann H A, Kirsch G E

Abstract excerpt

Aqueous exposure of critical residues in the selectivity region of voltage gated Na+ channels was studied by cysteine-scanning mutagenesis at three positions in each of the SS2 segments of domains III (D3) and IV (D4) of the human heart Na+ channel. Ionic currents were modified by charged cysteine-specific methanethiosulfonate (MTS) reagents, (2-aminoethyl)methanethiosulfonate (MTSEA+) and...

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Source

Identifiers

PMID: 9002421
DOI: 10.1007/s002329900154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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