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Article

Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.

The Journal of physiology - 1 Jul 2007

Sheets Michael F, Hanck Dorothy A

Abstract excerpt

The anti-arrhythmic drug lidocaine has been shown to have a lower affinity for block of voltage-gated sodium channels at hyperpolarized potentials compared to depolarized potentials. Concomitantly, lidocaine reduces maximum gating charge (Qmax) by 40% resulting from the complete stabilization of the S4 in domain III in an outward, depolarized position and partial stabilization of the S4 in domain IV in wild-type...

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Source

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Identifiers

PMID: 17510181
DOI: 10.1113/jphysiol.2007.134262
PMCID: PMC2075305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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