Article
Molecular basis for pharmacological differences between brain and cardiac sodium channels.
Pflugers Archiv : European journal of physiology - 1 Oct 1992
Heinemann S H, Terlau H, Imoto K
Abstract excerpt
Sodium channels from brain and heart, whose primary structures are known, differ in their sensitivity to block by the guadinium toxins tetrodotoxin and saxitoxin and to block by external Zn2+ and Cd2+. Studies using site-directed mutagenesis have identified the SS2 and adjacent regions of all four repeats as critical determinants for toxin sensitivity. Within and in the immediate vicinities of the SS2 segments,...
Topics
- Animals
- Brain
- Cations, Divalent
- Drug Resistance
- Ion Channel Gating
- Mutation
- Myocardium
- Rats
- Saxitoxin
- Sodium Channels
- Tetrodotoxin