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Article

P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements.

The Journal of general physiology - 1 Jul 1997

Tsushima R G, Li R A, Backx P H

Abstract excerpt

Replacement of individual P-loop residues with cysteines in rat skeletal muscle Na+ channels (SkM1) caused an increased sensitivity to current blockade by Cd2+ thus allowing detection of residues lining the pore. Simultaneous replacement of two residues in distinct P-loops created channels with enhanced and reduced sensitivity to Cd2+ block relative to the individual single mutants, suggesting coordinated Cd2+...

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Identifiers

PMID: 9234171
DOI: 10.1085/jgp.110.1.59
PMCID: PMC2229360

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Source receipt: pubmed, retrieved 7 Sept 2026.

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